Call: (414) 763-6910    Fax: 414-763-6911
Call: (414) 763-6910    Fax: 414-763-6911
Location: 2675 N. Mayfair Rd. Suite 400, Milwaukee, WI 53226 Get Directions

Mdd Graph

Background information on MDD

  • 1 out of 6 people will experience a major depressive episode in their lifetime (1)
  • 15 million adults in the US suffer a major depressive episode in a year (1)

Mainstays of treatment

The mainstays of treatment with strong empirical data supporting their effectiveness are pharmacotherapy (medication therapy), neuromodulatory techniques and evidence-based psychotherapy (e.g. cognitive behavioral therapy). However, many patients still continue to report insufficient relief.


  • A widely cited Star D trial shows that up to half of the patients fail to respond to first line treatment and each successive treatment has a lower and lower remission rate from depression. (2)
  • Pharmacotherapy also often presents various side effects that can be difficult to tolerate.


  • Although they provide invaluable tools for building someone's internal resilience, treatment is often lengthy and best optimized with a well-trained therapist. This treatment modality is often insufficient as monotherapy, especially in more challenging cases.

Electroconvulsive therapy

  • To date, one of the most effective treatment modalities for major depression with the highest rate of remission.
  • However, the patient is exposed to the risks of anesthesia and due to this there is a smaller pool of medically suitable candidates. It is also associated with side effects such as headache, nausea, and transient memory loss.

Transcranial Magnetic Stimulation (TMS)

  • This is an FDA approved non-medication based option for treating a major depressive episode. It generates a magnetic field that turns on and off quickly, generating an electric current. This technology targets the part of the brain specifically involved in mood regulation. The electric current activates cells in the brain that tend to be under-active in depression and promotes release fo neurotransmitters that help mood. TMS also utilizes a concept termed neuroplasticity. By stimulating the left prefrontal cortex, the brain can be induced to create new pathways for effective transmission. This is typically and best practiced as an adjunct to other existing treatment modalities.
  • This has been an extensively studied and effective treatment for major depressive episodes.
  • This is a very well tolerated treatment modality.
  • TMS can be a very useful adjunct to pharmacotherapy/medication therapy and studies found that TMS conducted in proximity to evidence-based psychotherapy can increase effectiveness of treatment. (3)
  • Why deep TMS as opposed to other TMS facilities?

    • Deep TMS is uniquely offered through Brainsway in comparison to other figure of 8 coils in the Milwaukee area.
    • It is based on patents licensed from the National Institutes of Health (NIH), enabling non-invasive activation of deep brain structures that can address a wide range of neurosychiatric conditions
    • In a large-scale double-blinded multicenter randomized controlled trial with hundreds of patients, about a third of treatment resistant patients achieved remission and 44% showed response to treatment on completion of treatment with very low discontinuation rates. In real life settings, remission rates were found to be as high as 50% and response rates as high as 75%. (4, 5)
    • Deep TMS technology has also been utilized at various major academic centers including Duke University Medical Center, Johns Hopkins, McLean Hospital (a Harvard Medical School affiliate), and Columbia University Medical Center
    • Deep TMS technology also stimulates a broader area and produces a deeper effective electric field than figure of 8 coils. (6)
    • There are ongoing or completed trials regarding application of TMS technology to conditions such as schizophrenia, bipolar depression, PTSD, Alzheimer's disease, Parkinson's disease, multiple sclerosis, autism, smoking cessation, chronic pain, and stroke rehabilitation

    Why New Frontiers TMS LLC?

    • Dr. Hong Yin is not only experienced at providing high quality TMS. She is a strong advocate of practicing evidence based (in other words, substantiated in the medical literature to be effective) treatments whether it is TMS or not. Numerous studies have demonstrated the efficacy of a multipronged approach as being superior to monotherapy/single modality therapy in various psychiatric conditions. The reason being is that how we feel is affected by a multitude of factors at play. To form an effective plan, we must have a good idea of what the underlying causes are. At New Frontiers TMS LLC, our aim is to get an accurate diagnostic picture and then cater your treatment/medical advice to your individual circumstances. These may often include evidence-based medication management (the right class, mechanism of action, duration of treatment, and dosage) as well as various psychotherapy modalities (e.g. dialectical behavioral therapy, cognitive behavioral therapy, exposure response prevention). She is interested in not only offering you treatment options that are helpful but in helping you formulate a plan to help you sustain the therapeutic benefits.
    • Accessibility: if you have limited insurance, no insurance, or are uncertain of your benefits, please do not hesitate to contact us at all. We would be more than happy to provide an initial phone conversation free of charge to discuss if potentially deep TMS could be of benefit in your case.
    • Sources

      1. Kessler RC, et al. National Comorbidity Survey Replication. JAMA (2003)

      2. Rush AJ, et al. (2006). Acute and Longer-Term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report. Am J Psychiatry, 163:1905-1917.

      3. Donse, L, Padberg, F, Sack, AT, Rush, AJ, & Arns, M. (2017). Simultaneous rTMS and psychotherapy in major depressive disorder: Clinical outcomes and predictors from a large naturalistic study. Brain Stimulation. doi:

      4. Levkovitz Y, et al. World Psychiatry 2015; 14:64-73.

      5. Brainsway Ltd. Data on file.

      6. Guadagnin V, et al. Deep Transcranial Magnetic Stimulation: Modeling of Different Coil Configurations. IEEE Trans Biomed Eng. 2016;63:1543-50.
      Kessler RC, et al. National Comorbidity Survey Replication. JAMA (2003)

      Don’t live with the misery of depression, anxiety, bipolar disorder, PTSD or another mental health issue. Schedule an appointment wiith a female psychiatrist by calling 414-763-6910 or use our convenient Request an Appointment form. We welcome patients from Milwaukee, New Berlin, Waukesha, Wauwatosa, West Allis and surrounding cities and towns.

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2675 N. Mayfair Rd. Suite 400, Milwaukee WI 53226